Gene Therapy of Parkinsons is Disease

Manual Therapy Choices: A General Approach to Parkinsons Disease

In treating dysfunction, it is normal for most therapists to use a variety of modalities and methods including myofascial release, muscle-energy techniques, positional-release techniques and many more. The assumption must be that different tools achieve different effects, and the ones we choose reflect our perception as to the needs of the individual and/or of the tissues involved. Sledgehammer...

If Gene Therapy Is the Cure, What Is the Disease?

Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease

Increasing evidence points to defects in autophagy as a common denominator in most neurodegenerative conditions. Progressive functional decline in the autophagy-lysosomal pathway (ALP) occurs with age, and the consequent impairment in protein processing capacity has been associated with a higher risk of neurodegeneration. Defects in cathepsin D (CD) processing and α-synuclein degradation causin...

Automatic, unsupervised classification of dyskinesia in patients with Parkinsons Disease

One of the characteristic symptoms of patients with Parkinson Disease (PD) is a rigidity of movement. These symptoms disappear after administration of Levodopa. However, the long-term use of levodopa causes involuntary movements (dyskinesia). A proper diagnosis requires an automatic, unsupervised method for the detection and classification of levodopa induced dyskinesia. The main problem, howev...

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinsons disease

Amy R. Dunn, Kristen A. Stout, Minagi Ozawa, Kelly M. Lohr, Alison I. Bernstein, Yingjie Li, Minzheng Wang, Carmelo Sgobio, Namratha Sastry, Huaibin Cai, W. Michael Caudle, and Gary W. Miller* 1. Rollins School of Public Health, Emory University, Atlanta, GA 30322. 2. Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322. 3. Transgenics Section, Laboratory of Neurogenetics, ...